Please mark your calendars for Thursday, October 26, when the Dean’s Workshop, “Krios and Cryo-Electron Microscopy at Yale,” will take place from 1 to 5 p.m., in The Anlyan Center Auditorium.

Three scientists were awarded the Nobel Prize in Chemistry this month for their development of this revolutionary new technology, that has helped further elucidate biological structures in atomic detail. Yale recently purchased a Titan Krios cryo-electron microscope, which greatly enhances our ability to examine the characteristics of biological specimens. This device also brings cryo-electron tomography (cryo-ET)—an advance that builds upon cryo-EM—to our campus. This workshop will describe the cryo-EM resources available to scientists at Yale, and highlight some of the exciting new scientific advances made by Yale investigators using cryo-EM and cryo-ET.

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1:00 p.m. Introduction
Michael C. Crair, PhD, Deputy Dean for Scientific Affairs (Basic Science Departments); William Ziegler III Professor; Departments of Neuroscience and Ophthalmology & Visual Science, Yale School of Medicine

1:10 p.m. Overview of Cryo-EM at Yale
Xinran Liu, MD, PhD, Research Scientist; Director of Electron Microscopy Core Facility, Yale School of Medicine
Yong Xiong, PhD, Associate Professor; Department of Molecular Biophysics and Biochemistry; Director of Science Hill Cryo-EM Facility, Yale University

1:35 p.m. Introduction to Titan Krios
Shenping Wu, PhD, Research Scientist; Director of Titan Krios Core Facility, Yale University

2:20 p.m. Computational magic behind single-particle Cryo-EM Fredrick J. Sigworth, PhD, Professor; Departments of Cellular and Molecular Physiology, Biomedical Engineering, and of Molecular Physics and Biochemistry, Yale School of Medicine

3:10 p.m. From X-Ray crystallography to Cryo-EM: Single-particle applications Yong Xiong, PhD, Associate Professor; Department of Molecular Biophysics and Biochemistry, Yale University

4:00 p.m. The future of cryo-electron tomography: Cell biology at high resolution
Jun Liu, PhD, Associate Professor; Department of Microbial
Pathogenesis, Microbial Sciences Institute, Yale School of Medicine